Managing several projects that share resources or have interconnected deliverables may become complicated quickly. Primavera P6 does this well, but only if you leverage its global and cross-project dependence features intelligently.
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EPS (Enterprise Project Structure) – Organize projects hierarchically by business unit or portfolio. 
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Cross-Project Links – Create dependency ties between WBS items across different projects. 
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Shared Calendars/Codes – Keep milestones and reports aligned through global attributes. 
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Enable Inter-Project Scheduling – Activate this option to recalculate paths that span multiple projects. 
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Portfolio View – View multiple projects at once to detect shared risks and constraints. 
When applied correctly, this enables true multi-project alignment, visibility, and smarter forecasting at the portfolio level.